Anti-Viral Pharmaceutical Intermediates Valacyclovir Hydrochloride CAS 124832-27-5
Product Description
| Product Name: | Valacyclovir hydrochloride |
| CAS: | 124832-27-5 |
| MF: | C13H21ClN6O4 |
| MW: | 360.8 |
| EINECS: | 641-092-8 |
Valacyclovir hydrochloride, an orally active L-valyl ester of the potent antiviral agent aciclovir, was launched in 1995 in the United Kingdom for the treatment of herpes simplex virus (HSV) infections of the skin and mucous membranes, including initial and recurrent enital herpes. As a prodrug, valaciclovir has an improved pharmacokinetic profile to aciclovir. It is rapidly absorbed after oral administration and extensively converted to aciclovir via first-pass metabolism to achieve plasma levels of aciclovir comparable to those seen with aciclovir via i.v. route. Valacyclovir is then activated selectively in virus-infected cells by viral thymidine kinase to form aciclovir triphosphate in a stepwise fashion. This active species inhibits viral DNA polymerase via irreversible binding to the active site of the enzyme. Once aciclovir is incorporated into the elongating viral DNA, it terminates replication of the viral DNA strand, an antiviral mechanism unique to aciclovir. Valacyclovir is reportedly in clinical trials for the suppression of cytomegalovirus infection and disease in renal transplant patients.
Application:
Valaciclovir hydrochloride hydrate is the l-valine ester of acyclovir, which is the body prodrug of acyclovir. Acyclovir is hydrolyzed into acyclovir immediately after entering the body. It is used for the treatment of varicella zoster and herpes simplex virus type I and II infection, including incipient and recurrent genital herpes virus infection.
Packaging Details
25kg carton drum (32cm*58cm)or 1kg foil bag (10cm*15cm) or by request of clients
Port:TIANJIN
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Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services.
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The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services.
We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market.
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